Analysis performed on 2024-09-30 10:20:46
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 44328 | 601 | 43727 | 21938 |
| Archaea | 3239 | 87 | 3152 | 311 |
| Vertebrata | 978 | 277 | 701 | 416 |
| Mammals | 354 | 51 | 303 | 130 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 597 | 82 | 651 |
| Domains | |
|---|---|
| Current Study | 1, 62 |
| Guo et al (2010) | 20, 40 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 536 | 61 | 597 | 8.786885 |
| Number of Variants | 643 | 90 | 733 | 7.144444 |
| Number of Pathogenic Variants | 79 | 3 | 82 | 26.333333 |
| Number of Benign/Unknown Variants | 564 | 87 | 651 | 6.482759 |
| Fisher exact test | 0.011114 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 576 | 21 | 597 | 27.428571 |
| Number of Variants | 716 | 17 | 733 | 42.117647 |
| Number of Pathogenic Variants | 81 | 1 | 82 | 81.000000 |
| Number of Benign/Unknown Variants | 635 | 16 | 651 | 39.687500 |
| Fisher exact test | 0.709329 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 536 | 61 | 0.92 (0.01) | 0.71 (0.03) | 9.813e-01 | 7.362e-01 | 26872.50 | 7.54e-17 |
| Guo et al (2010) | 576 | 21 | 0.90 (0.01) | 0.90 (0.03) | 9.771e-01 | 9.577e-01 | 6946.50 | 1.23e-01 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.